Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide
Abstract Background Tumor-associated macrophages (TAMs) are the major component of tumor-infiltrating immune cells.Macrophages are broadly categorized as M1 or M2 types, and TAMs have been shown to express an M2-like phenotype.TAMs promote tumor progression and contribute to resistance to chemotherapies.Therefore, M2-like TAMs are potential targets